个人简介

天津理工大学化学化工学院讲师，硕士生导师。主要从事药物固体形态包括药物晶型、盐型、共晶等的制备与性质研究，以及离子液体药物和低共熔溶剂载药制剂的开发研究。主持国家自然科学基金青年基金项目和多项横向课题，以第一作者和通讯作者共发表学术论文13篇。

主讲课程

药物分析学（双语），制药工程专业开放实验

学术经历

2011.09-2015.06  南开大学药学专业学习，获学士学位
2015.08-2020.06  中山大学药剂学专业学习，获博士学位
2020.12-至   今  天津理工大学化学化工学院 讲师，硕导

科研项目

1. 国家自然科学基金青年科学基金项目：基于低共熔溶剂的药物共晶合成及其机制研究（22101204），2022.01-2024.12，30万，第一；
2. 国家自然科学基金面上项目：抗肿瘤药-药纳米共晶的可控合成与增溶增效研究（22271220），2023.01-2026.12，54万，第三；
3. 横向课题：甾体激素类药物共晶的固态分析研究，2021.5-2022.5，5万，第一；
4. 横向课题：化合物CMI2109-2盐型筛选，2023.9-2023.11，4.35万，第一；
5. 横向课题：CMI2109-2盐型化合物晶型筛选研究，2023.11-2024.01，4.35万，第一。

代表性论文

1. Xia-Lin Dai, Bo-Wen Pang, Wen-Ting Lv, Jian-Feng Zhen, Lu Gao, Cai-Wen Li, Jing Xiong,* Tong-Bu Lu, Jia-Mei Chen*, Improving the physicochemical and pharmacokinetic properties of olaparib through cocrystallization strategy. Int. J. Pharmaceut. 2023, 647, 123497.
2. Min Zhang,1 Dai-Lin Gu,1 Jian-Feng Zhen, Tong-Bu Lu, Xia-Lin Dai* and Jia-Mei Chen, A novel drug–drug cocrystal of tegafur and myricetin: optimized properties of dissolution and tabletability. CrystEngComm 2023, 25, 6171-6179.
3. Chao Wu, Lu Gao, Jing Xiong, Xia-Lin Dai,* Wei Gao, Tong-Bu Lu, Jia-Mei Chen*, Salts of rucaparib with dicarboxylic acids: synthesis, crystal structures and solubility. CrystEngComm 2022, 24, 7813-7820.
4. Guan-Lan Huang1, Ling Yang1, Bo-Ying Ren, Xin-Yue Lv, Ling-Yi Song, Xia-Lin Dai*, Jia-Mei Chen*, Simultaneously improving the physicochemical and pharmacokinetic properties of vemurafenib through cocrystallization strategy. J. Drug Deliv. Sci. Tec. 2022, 70, 103230.
5. Jun-Long Jia, Xia-Lin Dai,* Hao-Jie Che, Meng-Ting Li, Xiao-Mei Zhuang, Tong-Bu Lu and Jia-Mei Chen,* Cocrystals of regorafenib with dicarboxylic acids: synthesis, characterization and property evaluation. CrystEngComm 2021, 23, 653-662.
6. Jie Wang, Xia-Lin Dai,* Tong-Bu Lu and Jia-Mei Chen,* Temozolomide−hesperetin drug−drug cocrystal with optimized performance in stability, dissolution, and tabletability. Cryst. Growth Des. 2021, 21, 838-846.
7. Bo-Ying Ren, Xia-Lin Dai,* Jie Wang, Chao Wu, Tong-Bu Lu and Jia-Mei Chen*, Cocrystallization of axitinib with carboxylic acids: preparation, crystal structures and dissolution behavior. CrystEngComm 2021, 23, 5504-5515.
8. Xia-Lin Dai, Jia Yao, Jun-Hui Deng, Yong-Hui Mo, Tong-Bu Lu and Jia-Mei Chen,* Solubility and permeability improvement of allopurinol by cocrystallization. Cryst. Growth Des. 2020, 20, 5160-5168.
9. Xia-Lin Dai, Chao Wu, Jin-Hui Li, Lian-Chao Liu, Xin He, Tong-Bu Lu and Jia-Mei Chen,* Modulating the solubility and pharmacokinetic property of 5-fluorouracil via cocrystals. CrystEngComm 2020, 22, 3670-3682.
10. Xia-Lin Dai, Alexander P. Voronin, Yong-Liang Huang, German L. Perlovich, Xing-Hua Zhao, Tong-Bu Lu and Jia-Mei Chen,* 5-Fluorouracil cocrystals with lipophilic hydroxy-2-naphthoic acids: crystal structures, theoretical computations and permeation studies. Cryst. Growth Des. 2020, 20, 923-933.

专利专著

1、戴霞林，吕文婷，陈嘉媚，一种奥拉帕尼与丙二酸的共晶及其制备方法，专利号202010707895.8。
2、戴霞林，贾军龙，李梦婷，陈嘉媚，一种瑞戈非尼与辛二酸的共晶及其制备方法，专利号202010702741.X。