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教授
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刘玉明
2014-10-21 15:50:44   审核人:   (点击: )

 

刘玉明简介

姓名

刘玉明

性别

出生年月

1968.07

学历学位

博士

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职称

教授

系别

制药工程系

导师类型

硕导

电话

13702182883

Email

liuyuming@tjut.edu.cn

办公/科研室

19号楼407

所属学科

100701药物化学;086000生物与医药;070300化学;085600材料与化工

研究

方向

1. 具有重要生物活性天然先导化合物的发现及优化;

2. 针对重大疾病的创新药物研制;

3. 上市药品的质量标准提升和生产工艺改进。

讲授课程:本科生课程:天然药物化学;研究生课程:植化方法学

主要科研项目及代表性成果(包括鉴定项目、论文、专著、获奖、专利等)

科研项目:  

1.   国家自然科学基金面上项目:贝母属植物中多靶向抗阿尔茨海默病活性成分及作用机制研究(31970373) 2020.01-2023.1258万,项目负责人;

2.   国家自然科学基金面上项目:维药斯亚旦抗肝癌药效物质基础研究(81073153)2011.01-2013.1232万,项目负责人;

3.     天津市科技发展计划项目:35种植物药标准提取物的研究(05ZHGCGX01500)2005.04-2007.0350万,参加;

4.     国家自然科学基金项目:民族药马蹄金生物活性成分的研究(39960081)2000.01-2002.1212万,参加; 

5.     教育部“国家级大学生创新创业训练计划项目”:维吾尔药斯亚旦中抗肝癌先导物的发现(201210060001)2012.09-2014.072万,指导教师;

6.   天津市教委科研项目:两亲性树型共聚物的分子设计及其多功能靶向药物载体的构建(20110501)2011.11-2014.104万,参加。

论文:

1.      Xiao   Liu, Lu Sun, Qing-Hua Liu, Bao-Quan Chen*, Yu-Ming Liu*.   Synthesis, characterization and anti-hepatoma activity of new hederagenin   derivatives. Mini-Reviews in Medicinal Chemistry, 2020, 20 (3):   252-257.

2.      Rong   Cai, Li-Ning Wang, Jing-Jing Fan, Shang-Qi Geng, Yu-Ming Liu*. New   4-N-phenylaminoquinoline derivatives as antioxidant, metal chelating and   cholinesterase inhibitors for Alzheimer’s disease. Bioorganic Chemistry,   2019, 93: 103328.

3.      Jun   Zhu, Li-Ning Wang, Rong Cai, Shang-Qi Geng, Ya-Fei Dong, Yu-Ming Liu*.   Design, synthesis, evaluation and molecular modeling study of   4-N-phenylaminoquinolines for Alzheimer disease treatment. Bioorganic   & Medicinal Chemistry Letters, 2019, 29(11): 1325-1329.

4.      Hai-Ying   Liu, Hai-Xin Wang, Xin Li, Zheng Wu, Cai-Wen Li, Yu-Ming Liu*, Wei   Li, Bao-Quan Chen*. Synthesis, antitumor and antimicrobial evaluation of   novel 1,3,4-thiadiazole derivatives bearing disulfide bond. Medicinal   Chemistry Research, 2018, 27(8): 1929-1940.

5.      Cheng-Long   Li, Yu-Ming Liu, Zhe Sun, Jin-Yun Zhang, Mei-Yan Liu, Chen Zhang, Qian   Zhang, Hong-Juan Wang, Xu-Guang Liu. Synthesis, characterization, and   properties of bis-BN ullazines. Organic Letters, 2018, 20 (10):   2806–2810.

6.      Yu-Ming Liu, Ya-Dong Feng, Xi Lu,   Jian-Bing Nie, Wei Li, Li-Ning Wang,Li-Jun Tian, Qing-Hua Liu. Isosteroidal   alkaloids as potent dual-binding site inhibitors of both acetylcholinesterase   and butyrylcholinesterase from the bulbs of Fritillaria walujewii. European   Journal of Medicinal Chemistry, 2017, 137: 280-291.

7.      Yu-Ming   Liu, Jian-Bing Nie, Lin-Na Sun, Qing-Hua Liu. Cytotoxic   compounds from Scolopendra subspinipes mutinlans. Heterocycles,   2016, 92 (2): 346-352.

8.      Bao-Lin   Li, Bo Li, Rui-Lian Zhang, Ji-Jun Zhao, Xue-Feng Wang, Yu-Ming Liu,   Yan-Ping Shi, Jin-Biao Liu, Bao-Quan Chen. Synthesis and antiproliferative   evaluation of novel 1,2,4-triazole derivatives incorporating   benzisoselenazolone scaffold. Bioorganic & Medicinal Chemistry Letters, 2016,   26 (4): 1279-1281.

9.      Xiao-Yun   Fu, Sha Li, Fen Jing,_Xue-Feng Wang, Bao-Lin Li, Ji-Jun Zhao, Yu-Ming Liu,   Bao-Quan Chen. Synthesis and biological evaluation of novel 1,3,4-thiadiazole   derivatives incorporating benzisoselenazolone scaffold as potential antitumor   agents. Medicinal Chemistry, 2016, 12 (7):   631-639.

10.   Lu   Sun, Yu-Ming Liu*, Bao-Quan Chen, Qing-Hua Liu. New   phenolic compounds from the seeds of Nigella glandulifera and their   inhibitory activities against human cancer cells. Bioorganic & Medicinal   Chemistry Letters, 2015, 25 (18): 3864-3866.

11.   Li-Na   Xuan, Peng Wang, Kai Zhang, Yan-Ping Shi, Yu-Ming Liu, Tao Zhu, Bao-Quan   Chen. Synthesis and in vitro antiproliferative activity of novel benzisoselenazolone   derivatives. Medicinal Chemistry Research, 2015, 24 (2):   543-552.

12.   Jie   Zhao, Li-Na Xuan, Hai-Chuan Zhao, Ji Chen, Xiao-Yun Fu, Sha Li, Fen Jing, Yu-Ming   Liu, Bao-Quan Chen. Synthesis   and antitumor activities of 1,3,4-thiadiazole derivatives possessing benzisoselenazolone   scaffold. Chemical Research in Chinese Universities,   2014, 30(5), 764-769.

13.   Kai   Zhang, Peng Wang, Li-Na Xuan, Xiao-Yun Fu, Fen Jing, Sha Li, Yu-Ming Liu,   Bao-Quan Chen. Synthesis and antitumor activities of novel hybrid molecules containing   1,3,4-oxadiazole and 1,3,4-thiadiazole bearing Schiff base moiety. Bioorganic   & Medicinal Chemistry Letters, 2014, 24 (22):   5154-5156.

14.   Yu-Ming   Liu, Yu-Hu Jiang, Qing-Hua Liu, Bao-Quan Chen. Indazole-type   alkaloids from the seeds of Nigella glandulifera. Phytochemistry   Letters, 2013, 6 (4): 556–559.

15.   Yu-Ming   Liu, Lu Sun, Qing-Hua Liu, Shi-Rong Lu, Bao-Quan Chen.   Dolabellane-type diterpene alkaloids from Nigella glandulifera. Biochemical   Systematics and Ecology, 2013, 49: 43–46.

16.   Ying-Li   Chen, Chun-Lan Zhou, Zhen-Dan Ge, Yu-Fa Liu, Yu-Ming Liu, Wei-Yi Feng,   Sen Li, Guo-You Chen, Tai-Ming Wei. Composition and potential anticancer activities of   essential oils obtained from myrrh and frankincense. Oncology   Letters, 2013, 6 (4): 1140–1146.

17.   Hai-Chuan   Zhao, Yan-Ping Shi, Yu-Ming Liu, Cai-Wen Li, Li-Na Xuan, Peng Wang,   Kai Zhang, Bao-Quan Chen. Synthesis and antitumor-evaluation of   1,3-selenazole-containing 1,3,4-thiadiazole derivatives. Bioorganic   & Medicinal Chemistry Letters, 2013, 23 (24):   6577-6579.

18.   Yu   Feng, Yu-Ming Liu*,   Qing-Hua Liu, Ying-Jie Lei. Nigelactone, new phthalide glucoside from   the seeds Nigella glandulifera. Heterocycles, 2012, 85 (12):   3015-3019.

19.   Jie   Zhao, Bao-Quan Chen, Yan-Ping Shi, Yu-Ming Liu, Hai-Chuan Zhao, Ji   Cheng. Synthesis and in vitro antitumor activity of 1,3,4-thiadiazole   derivatives based on benzisoselenazolone. Chinese Chemical Letters,   2012, 23 (7): 817-819.

20.   Zhen-Hua   Luo, Shuang-Yan He, Bao-Quan Chen, Yan-Ping Shi, Yu-Ming Liu, Cai-Wen   Li, and Qiu-Sheng Wang. Synthesis and in Vitro Antitumor Activity of   1,3,4-Oxadiazole Derivatives Based on Benzisoselenazolone. Chemical &   Pharmaceutical Bulletin, 2012, 60 (7): 887–891.

21.   Zhen-Hua   Luo, Bao-Quan Chen, Shuang-Yan He, Yan-Ping Shi, Yu-Ming Liu, Cai-Wen   Li. Synthesis and antitumor-evaluation of 1,3,4-thiadiazole-containing   benzisoselenazolone derivatives. Bioorganic & Medicinal Chemistry Letters,   2012, 22 (9): 3191-3193.

22.   Yu-Ming   Liu, Qing-Hua LiuBao-Quan   Chen. A new flavonol glycoside from the seeds of Nigella glandulifera.   Natural Product Research, 2011, 25 (14):1334-1338.

23.   Ze   Tian, Yu-Ming Liu, Si-Bao Chen, Jun-Shan Yang, Pei-Gen Xiao, Liao   Wang, Erxi Wu. Cytotoxicity of two triterpenoids from Nigella glandulifera,   Molecules, 2006, 11 (9): 693-699.

24.   Yu-Ming   Liu, Jun-Shan Yang, Qing-Hua Liu. A new alkaloid and its   artificial derivative with indazole ring from Nigella glandulifera. Chemical   & Pharmaceutical Bulletin, 2004, 52 (4): 454-455.

25.     刘玉明,姜海燕,陈宝泉,雷英杰,牛心蕙.天然药物化学教学与文化传承培养的思考.教育现代化,2019,683:23-25.

26.     刘玉明,田丽珺,胡栋,聂建兵. 4-N-苯胺基喹啉衍生物的合成及胆碱酯酶抑制活性.高等学校化学学报,2017, 383):392-397.

27.     艾双艳,李卫国,冯亚东,田丽珺,刘玉明*.全蝎化学成分的研究.中成药,2017, 39(8): 1639-1641.

28.     史林琦,路熹,孟令武,吕文婷,刘庆华,刘玉明*.新疆贝母鳞茎化学成分的分离与鉴定.中药材,2017, 40(9): 2098-2100.

29.     李静,刘玉明*,刘庆华,李微.瘤果黑种草子中磷脂类成分的研究.中成药,201537(1)128-131.

30.     刘玉明,蒋玉虎,张海滨.小儿清肺颗粒质量标准研究.中药新药与临床药理,2014,255):610-614.

31.     蒋玉虎,刘玉明*,孙璐,李静.炉贝母不同提取物中贝母辛和贝母素乙含量的HPLC-ELSD测定.时珍国医国药,2014,   255):1051-1053.

32.     刘玉明,路熹,蒋玉虎,刘庆华,高继光. HPLC-ELSD同时测定新疆贝母中贝母辛和贝母素乙的含量.中药材,2014, 375):827-829.

33.     刘玉明,郑丽萍,王家美. 秦艽中龙胆苦苷纯化工艺的正交实验法优选.时珍国医国药,2012, 237):1596-1598.

34.     刘玉明,李彩文.   天然药物化学教学方法的探讨.中国医药导报,2011,826):120-122.

35.     史艳萍, 陈宝泉, 麻静, 刘玉明, 李彩文. 2-(2-取代-1,3,4-噻二唑-5-)-苯并异硒唑-3(2H)-酮衍生物的合成及体外抗癌活性, 化学学报2011, 69(21): 2561-2566.  

36.     杨梅,刘玉明,高瑞昶. 高效液相色谱法测定桑叶中1-脱氧野尻霉素的含量.武警医学,2007,18(2)121-123.

37.     刘玉明,杨峻山,刘庆华. 瘤果黑种草子化学成分的研究.中国中药杂志,2005,3013):980-983.

38.     刘玉明,杨峻山,刘庆华. 红花化学成分研究.中药材,2005,284):288-289.

39.     梁光义,刘玉明,曹佩雪,徐必学,郝小江. 民族药马蹄金中多羟基化合物的研究.中南药学,2003,12):105-107.

40.     刘玉明,梁光义,徐必学. 苗族药马蹄金化学成分的研究.天然产物研究与开发,2003,151):15-17.

41.     刘玉明,梁光义,张建新,武孔云,徐必学,罗波. 马蹄金化学成分的研究.中国药学杂志,2002,378):577-579.

专著:

 1. 刘玉明.《实用天然产物手册》萜类化合物分册(杨峻山主编)之第六章三环三萜类化合物,北京:化学工业出版社,2005.4 

专利: 

1.   刘玉明,范晶婧,艾双艳,冯亚东. 国家发明专利.全蝎中胍类生物碱钳蝎碱甲和/或钳蝎碱乙的提取方法及医药用途,申请号CN201911232934.7

2.   刘玉明,孙琳娜,聂建兵,田丽珺.国家发明专利.少棘蜈蚣中喹啉类生物碱作为治疗肿瘤药品的制备及应用,授权专利号ZL201510029556.8

3.    刘玉明,陈宝泉,李彩文.国家发明专利.一种从杜仲果中提取桃叶珊瑚苷的工艺方法,授权专利号ZL201010297478.7

4.    刘玉明,孙琳娜,李静.国家发明专利.一种从斯亚旦中提取异株五加甲苷的方法,申请号CN201310619087.6

5.      刘玉明,冯亚东,孙璐,聂建兵,路熹,孙琳娜.国家发明专利.常春藤皂苷元类化合物作为治疗肝癌药品的应用及其制备,申请号CN201410214316.0

6.      陈宝泉,罗振华,刘玉明,史艳萍,赵海川,程吉,赵婕.国家发明专利.2-(2-取代-1,3,4-噁二唑-5-)-苯并异硒唑酮衍生物的制备方法,申请号CN201110411172.4

7.      陈宝泉,史艳萍,麻静,卢学磊,李彩文,刘玉明.国家发明专利.基于苯并异硒唑酮结构的1,3,4-噻二唑(噁二唑)衍生物及其制备方法和应用,授权专利号ZL201010213585.7

8.      梁光义,徐必学,刘昌孝,黄正明,曹佩雪,蔡泽贵,刘玉明.国家发明专利.N-(N-苯甲酰基-苯丙氨酰基)-苯丙氨酸二肽衍生物及其制备方法和用途,授权专利号ZL200610201016.4

9.      梁光义,刘玉明,徐必学.国家发明专利.苯丙氨醇类化合物作为制备治疗乙肝药品的应用及其制备方法,授权专利号ZL02160309.X

获奖: 

1. 天津科技进步三等奖(2008年度),35种植物药标准提取物的研究。

 

 

 

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