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高辉
2019-04-15 14:34:18   审核人:   (点击: )

高辉简介

姓名

高辉

性别

出生年月

1973.12

学历学位

博士

高辉

职称

教授

系别

制药系

导师类型

博导

电话

022-60214251

Email

Hgao@tjut.edu.cn

办公/

科研室

19号楼501

所属学科

0703 化学   /100701 药物化学/化学工程/制药工程

研究

方向

1. 生物医用高分子合成及其性能研究

2. 抗癌药物、蛋白质、肽类药物等的缓、控释体系

3. 环境响应性智能给药系统

讲授课程: 药用高分子材料 药事管理学 药学专业英语

人才称号:教育部新世纪优秀人才支持计划;“天津市131创新型人才培养工程”第一层次人选

学术兼职:国家自然科学基金评阅人,担任Adv. Mater., ACS App. Mater. & Inter., Mol. Pharm.,   Biomacromolecules, J. Control. Release, Eur. J. Pharm. Biopharm.等期刊特邀审稿人。

主要科研项目及代表性成果(包括鉴定项目、论文、专著、获奖、专利等)

项目:

1. 国家自然科学基金项目:近红外聚集诱导发光和活性氧参与的高效基因载体的构建(21674080),2017.01-2020.1266万,主持;

2. 国家自然科学基金项目:基于beta-环糊精的反相高分子胶束的构建及其在肽类药物传输中的应用(21374079),2013.01-2017.1283万,主持;

3. 国家自然科学基金项目: beta-环糊精高分子的合成、反相胶束的构建及其在肽类药物控制释放中的应用(21244004),2013.01-2013.1210万,主持;

4. 国家自然科学基金项目:含多氢键给体的高分子的合成及其作为基因载体的性能研究(21074092),2011.01-2013.12, 35万,主持;

5. 天津市自然科学基金重点项目:聚集诱导发光成像指导下的靶向光动力学与基因联合治疗(18JCZDJC377002018.04-2021.03, 20万,主持;

6. 2012年入选天津市高校“中青年骨干创新人才培养计划”201212-201511月,45万,主持

7. 天津市自然科学基金:侧链降解型聚阳离子基因载体的合成及其性能研究(10JCYBJC26800),2010.10   -2013.0910万,主持;

8. 973计划前期专项:新型生物降解高分子纳米材料的合成及其环境响应性能(2009CB626612),2009.04-11.0855万元,与南开大学马建标教授合作项目;是天津理工大学方负责人(结题);

9. 天津市高等学校科技发展基金计划项目:羧基聚甲基丙烯酸甘油酯的合成及对阿霉素的控制释放200905052009.12-2012.123万元,主持(结题);

10. 教育部新世纪优秀人才支持计划,2012.01-2014.1250万,主持;

11. 2015年入选“天津市131创新型人才培养工程”第一层次人选2016.3-2018.3, 20万元主持;

12. 2017年入选天津市“学科领军人才培养计划”2017.09-2020.0860万元,主持;

13. 2017年入选天津市“特聘教授”2018.07-2023.06, 100万元,主持。

论文:

1.Y. X. Zhang, H. Fu, S. Chen, B. Q. Liu,   W. F. Sun, H. Gao*, Construction of an iridium(III)-complex-loaded MOF   nanoplatform mediated with a dual-responsive polycationic polymer for   photodynamic therapy and cell imaging, Chem. Commun., 2020,   DOI: 10.1039/C9CC09357E.

2.Y. X. Zhang, H. Fu, D.-E. Liu, J. X. An*, H. Gao*, Construction of biocompatible   bovine serum albumin nanoparticles composed of nano graphene oxide and AIEgen   for dual-mode  phototherapy bacteriostatic and bacterial tracking, J.   Nanobiotechnol., 2019, 17:104.

3.Y. X. Zhang, S. Chen, J. X. An, H. Fu, X. S. Wu, C.   C. Pang,* H. Gao*, Construction of an antibacterial membrane based on dopamine   and polyethylenimine cross-linked graphene oxide, ACS Biomater. Sci. Eng.,   2019, 5, 2732-2739.

4.H. Fu, Y. K. Huang, H. G. Lu, J. X. An, D.-E. Liu,   Y. X. Zhang, Q. X. Chen*, H. Gao*, A theranostic saponin   nano-assembly based on FRET of an aggregation-induced emission photosensitizer   and photon up-conversion nanoparticles, J. Mater. Chem. B, 2019,   7, 5286-5290.

5.S. Z. Yan, S. Chen, X. B. Gou, J. Yang, J. X. An, X.   Y. Jin, Y.-W. Yang*, L. Chen*, H. Gao*, Biodegradable supramolecular materials   based on cationic polyaspartamides and pillar[5]arene for targeting gram-positive   bacteria and mitigating antimicrobial resistance, Adv. Funct. Mater., 2019,   29, 1904683.

6.Y. Yu, C. C. Pang,* X. S. Jiang, Z. Y. Yang, J. B.   Ma, H. Gao*, Copolycarbonates based on a bicyclic diol derived from   citric acid and flexible 1,4-cyclohexanedimethanol: From synthesis to   properties, ACS Macro Lett., 2019, 8, 454-459.

7.C. C. Pang,* X. S. Jiang, Y. Yu, L. Chen,* J. B. Ma,   H. Gao*, Copolymerization   of natural camphor-derived rigid diol with various dicarboxylic acids: Access   to biobased polyesters with various properties, ACS Macro Lett., 2019,   8,1442-1448.

8.N. Song, X.-Y. Lou, L. J. Ma, H. Gao*, Y.-W.   Yang*, Supramolecular nanotheranostics based on pillarenes, Theranostics,   2019, 9, 3075-3093.

9.R. Yang, J. X. An,* H. J. Zhu, X. J. Yan, H. Gao*,   Multipronged design of theranostic nanovehicles with endogenous and exogenous   stimuli-responsiveness for precise cancer therapy, J. Mater. Chem. B, 2019,   7, 1160-1166.

10.H. J. Zhu, J. X. An, C. C. Pang, S. Chen, W. Li, J.   B. Liu, Q. X. Chen, H. Gao*, A multifunctional polymeric gene delivery   system for circumventing biological barriers, J. Mater. Chem. B, 2019,   7, 384-392.

11.X. J. Yan, Q. X. Chen, J. X. An, D.-E. Liu, Y. K.   Huang, R. Yang, W. Li, L. Chen*, H. Gao*, Hyaluronic acid/PEGylated   amphiphilic nanoparticles for pursuit of selective intracellular doxorubicin   release, J. Mater. Chem. B, 2019, 7, 95-102.

12.S. Chen, Q. X. Chen, S. Q. Dong, J. B. Ma, Y. W.   Yang, L. Chen*, H. Gao*, Polymer brush decorated MOF nanoparticles   loaded with AIEgen, anticancer drug, and supramolecular glue for regulating   and in situ observing DOX release, Macromol. Biosci., 2018, 18,   e1800317.

13.S. Chen, Q. Y. Li, X. Wang, Y. W. Yang*, H. Gao*,   Multifunctional bacterial imaging and therapy systems, J. Mater. Chem. B,   2018, 6, 5198-5214.

14.S. Chen, Q. X. Chen, Q. Y. Li, J. X. An, P. Sun, J.   B. Ma, H. Gao*, Biodegradable synthetic antimicrobial with   aggregation-induced emissive luminogens for temporal antibacterial activity and   facile bacteria detection, Chem. Mater., 2018, 30, 1782-1790.

15.D. E. Liu, J. X. An*, C. C. Pang, X. J. Yan, W. Li,   J. B. Ma, H. Gao*, Construction of bovine serum albumin/AIE-based   quaternary complexes for efficient gene transfection, Macromol. Biosci.,   2018, e1800359.

16.J. L. Zou, H. G. Lu*, X. W. Zhao, W. Li, Y. Guan, Y.   D. Zheng, L. J. Zhang, H. Gao*, A multi-functional fluorescent probe   with aggregation-induced emission characteristics: mitochondrial imaging,   photodynamic therapy and visualizing therapeutic process in zebrafish model, Dyes   Pigments, 2018, 151, 45-53.

17.C. C. Pang*, X. S. Jiang, Y. Yu, X. H. Liu, J. Y.   Lian, J. B. Ma, H. Gao*, Sustainable polycarbonates from a citric   acid-based rigid diol and recycled BPA-PC: from synthesis to properties, ACS   Sustainable Chem. Eng., 2018, 6, 17059-17067.

18.Y. K. Huang, Q. X. Chen, H. G. Lu, J. X. An, H. J.   Zhu, X. J. Yan, W. Li, H. Gao*, Near-infrared AIEgen-functionalized   and diselenide-linked oligo-ethylenimine with self-sufficing ROS to exert   spatiotemporal responsibility for promoted gene delivery, J. Mater. Chem.   B, 2018, 6, 6660-6666.

19.D.-E. Liu, Q. X. Chen, Y.-B. Long, J. B. Ma*, H.   Gao*, A thermo-responsive polyurethane organogel for norfloxacin   delivery, Polym. Chem., 2018, 9, 228-235.

20.N. G. Morsi,   S. M. Ali, S. S. Elsonbaty, A. A. Afifi, M. A. Hamad, H. Gao*, M Elsabahy*, Poly(glycerol   methacrylate)-based degradable nanoparticles for delivery of small   interfering RNA, Pharm. Dev. Technol., 2018, 23, 387-399.

21.X. Liu, C. Pang*, J. Ma, H. Gao*, Random copolycarbonates   based on a renewable bicyclic diol derived from citric acid, Macromolecules,   2017, 50 (20), 7949-7958.

22.S. Dong, Q. Chen, W. Li, Z. Jiang, J. Ma, H. Gao*,   Dendritic catiomer with MOF motif for construction of safe and efficient gene   delivery systems, J.   Mater. Chem. B, 2017,   5, 8322-8329.

23.J. Zhu, Q. Chen,* X. Yang, X. Chen, Z.   Li, D.-E Liu, W. Li, Y. Lei, H. Gao*, Polyplex micelle with pH-responsive PEG detachment and functional   tetraphenylene incorporation to promote systemic gene expression, Bioconjug. Chem., 2017, 28(11), 2849-2858.

24.Q. Li, Y. Wu, H. Lu, X. Wu, S. Chen, N. Song, Y.-W.   Yang*, H Gao*, Construction of supramolecular   nanoassembly for responsive bacterial elimination and effective bacterial   detection, ACS Appl. Mater. Interfaces, 2017, 9, 10180-10189.

25.Y Guan, H. Lu* , W. Li, Y. Zheng, Z. Jiang, J. Zou, H   Gao*, Near-infrared triggered upconversion polymeric nanoparticles based   on aggregation-induced emission and mitochondria targeting for photodynamic   cancer therapy, ACS Appl. Mater. Interfaces, 2017, 9,   26731-26739.

26.Y Zheng, H Lu,* Z Jiang, Y Guan, J Zou, X Wang, R   Cheng, H Gao*, Low-power white light triggered AIE polymer   nanoparticles with high ROS quantum yield for mitochondria-targeted and   image-guided photodynamic therapy, J. Mater. Chem. B, 2017, 5,   6277-6281.

27.T. Wang, Q. Chen, H. Lu W. Li, Z. Li, J. Ma, H.   Gao,* Shedding PEG palisade by temporal photo-stimulation and   intracellular reducing milieu for facilitated intracellular trafficking and   DNA releasing, Bioconjug. Chem. 2016, 27, 1949-1957.

28.X. Q. Han, Q. X. Chen, H. G. Lu, P. Guo, W. Li, G.   L. Wu, J. B. Ma, H. Gao*, Incorporation of an   aggregation-induced-emissive tetraphenylethene derivative into cationic gene   delivery vehicles manifested the nuclear translocation of uncomplexed DNA, Chem. Commun., 2016,   52, 3907-3910.

29.H. Lu*, Y. Zheng, X. Zhao, L. Wang, S.   Ma, X. Han, B. Xu, W. Tian, H. Gao*,   Highly efficient farRed/Near-infrared solid fluorophores:   aggregation-induced emission, intramolecular charge transfer, twisted molecular   conformation, and bioimaging application. Angew. Chem. Int. Ed., 2016, 55, 155 -159.

30.Y.   Long, W. Gu, C. Pang, J. Ma, H. Gao*, Construction of   coumarin-based cross-linked micelles with pH responsive hydrazone bond and   tumor targeting moiety, J. Mater. Chem .B, 2016, 4, 1480-1488.

31.C. Fan, C. Pang,* X. Liu, J. Ma, H. Gao*,   Self-curing furan-based elastic thermosets derived from citric acid, Green   Chem. 2016, 18, 6320-6328.

32.Y. Wu, Q. Chen, Q. Li, H. Lu, X. Wu, J. Ma, H. Gao*, Daylight-stimulated antibacterial activity for   sustainable bacterial detection and inhibition, J. Mater. Chem. B, 2016,   4, 6350-635.

33.J. J. Wen, H. G. Lu*, D. E. Liu, H. Gao*,   Fabrication of macroporous protein-containing films through the reverse   emulsions approach featuring beta-cyclodextrin-conjugated PEG-PLGA   copolymers, Chinese J. Polym. Sci., 2016, 34(6): 730-738.

34.X. Q. Han, Q. X. Chen, H.   G. Lu, J. B. Ma, H. Gao*, Probe intracellular trafficking of polymeric   DNA delivery vehicle by functionalization with aggregation-induced emissive   tetraphenylethene derivative, ACS Appl Mater Inter, 2015,   7, 28494-28501.

35.Q. Li, S Xu, H. Zhou, X. Wang, B. Dong, H. Gao*,   J. Tang*, Y. Yang*. pH   and glutathione dual-responsive dynamic cross-linked supramolecular network   on mesoporous silica nanoparticles for controlled anticancer drug release, ACS Appl. Mater. Interfaces, 2015, 7, 28656-28664.

36.X. Han, D. Liu, T. Wang, H. Lu, J. Ma, Q. Chen*, H.   Gao*, Aggregation-induced-emissive molecule incorporated into polymeric   nanoparticulate as FRET donor for observing doxorubicin delivery. ACS Appl. Mater. Interfaces, 2015, 7 (42), 23760-23766.

37.P. Guo, W. Gu, Q. Chen, H. Lu, X. Han, W. Li, H.   Gao*, Dual functionalized amino poly(glycerol methacrylate) with   guanidine and Schiff-base linked imidazole for enhanced gene transfection and   minimized cytotoxicity. J. Mater. Chem., B, 2015, 3, 6911-6918.  

38.Y. Wu, Y. Long, Q.-L. Li, S. Han, J. Ma, Y.-W.   Yang*, H. Gao*, Layer-by-layer (LBL) self-assembled biohybrid   nanomaterials for efficient antibacterial applications, ACS Appl. Mater.   Interfaces, 2015, 7, 17255-17263.

39.H. Gao,   H. Takemoto, Q. Chen, M. Naito, H. Uchida, X. Liu, K. Miyata*, K. Kataoka*,   Regulated protonation of polyaspartamide derivatives bearing repeated   aminoethylene side chains for efficient intracellular siRNA delivery with   minimal cytotoxicity. Chem. Commun., 2015, 51,   3158-3161.

40.W.-X. Gu, Q.-L. Li, H. Lu, L. Fang, Q. Chen, Y.-W.   Yang*, H. Gao*, Construction of stable polymeric vesicles based on   azobenzene and beta-cyclodextrin grafted poly(glycerol methacrylate)s for   potential applications in colon-specific drug delivery. Chem. Commun.,   2015, 51, 4715-4718.

41.W.-X. Gu, M. Zhu, N. Song, X. Du, Y.-W.   Yang, H. Gao*, Reverse micelles   based on biocompatible β-cyclodextrin conjugated polyethylene glycol block   polylactide for protein delivery. J. Mater. Chem. B,   2015, 3, 316-322.

42.Y. Z. Zhuang, W.   X. Gu, J. J. Yang, X. Y. Chen, H. Gao*, Supramolecular nanoparticles   constructed by balancing the forces between attractive host-guest and   repulsive electrostatic interactions in two positively charged polymers, RSC   Adv., 2015, 5 (117): 96464-96471.

43.X. Du, N. Song, Y-W Yang, G. Wu, J. Ma,   H. Gao*, Reverse micelles based on β-cyclodextrin-incorporated amphiphilic   polyurethane copolymers for protein delivery. Polym. Chem., 2014,   5300-5309.

44.W Gu, Y-W Yang, J Wen, H Lu, H Gao*,   Construction of reverse vesicles from pseudo-graft poly(Glycerol   Methacrylate)s via cyclodextrin-cholesterol interaction. Polym. Chem.,   2014, 5, 6344-6349.

45.Q-L Li, L-Z Wang, X. Qiu, Y-L Sun, P.   Wang, Y. Liu, F Li, A-D Qi, H. Gao*, Y-W Yang*,   Stimuli-responsive biocompatible nanovalve based on β-cyclodextrin modified   poly(glycidyl methacrylate). Polym. Chem., 2014, 5, 3389-3395.

46.Q-L Li, W Gu, H. Gao*,   Yang, Y.-W*, Self-assembly and applications of poly(glycidyl methacrylate)s   and their derivatives. Chem. Commun., 2014, 50, 13201-13215.

47.L. Wang, Y.-W. Yang, M. Zhu, G. Qiu, G.   Wu, H. Gao*, β-Cyclodextrin-conjugated amino poly(glycerol methacrylate)s   for efficient insulin delivery. RSC Adv., 2014, 4, 6478-6485.

48.Q-L Li, Y. Sun, Y   -L Sun, J. Wen, Y. Zhou, Q. Bing, L. Isaacs, Y Jin, H. Gao*, Y-W   Yang*, Mesoporous silica nanoparticles coated by   layer-by-layer self-assembly using cucurbit[7]uril for in vitro and in vivo   anticancer drug release. Chem Mater.,   2014, 26, 6418-6431.

49.D-E Liu, H. Han, H. Lu, G. Wu, Y. Wang,   J. Ma, H. Gao*, Synthesis of amphiphilic polyaspartamide   derivatives and construction of reverse micelles. RSC Adv., 2014,   4, 37130-37137.

50.H. Han, D-E Liu, H. Lu, W-X Gu, H.   Gao*, Construction of micelles based on biocompatible pseudo-graft   polymers via b-cyclodextrin/cholesterol interaction for protein delivery. RSC   Adv., 2014, 4, 40882-40891.

51.Y. Sun, Y-L Sun, L. Wang, J. Ma, Y-W   Yang*, H. Gao*, Nanoassembles constructed from mesoporous   silica nanoparticles and surface-coated multilayer polyelectrolytes for   controlled drug delivery. Micropor Mesopor Mater., 2014,   185, 245-253.

52.Z. Liang, M. Zhu, Y-W Yang, H. Gao*,   Antimicrobial activities of polymeric quaternary ammonium salts from   poly(glycidyl methacrylate)s. Polym. Adv. Technol., 2014, 25,   117-122.

53.H. Gao*,   Z. Liang, X. Wu, C. Li, Y-W Yang, G. Wu, J. Ma, Quaternized poly(Glycerol   Methacrylate)s for enhanced pDNA delivery. J. Controlled Release,   2013, 172, e104-e105.

54.C. Li, Y-W Yang,   Z-X Liang, G-L Wu, H. Gao,* Post-modification poly(glycidyl   methacrylate)s with alkyl amine and isothiocyanate for effective pDNA   delivery. Polym. Chem., 2013, 4, 4366-4374.

55.Z. Liang, X. Wu, Y-W Yang, C. Li, G.   Wu, H. Gao*, Quaternized amino   poly(glycerol-methacrylate)s for enhanced pDNA delivery. Polym. Chem.,   2013, 4, 3514-3523.

56.Y. Sun, H.   Gao*, Y-W Yang, A. Wang, G. Wu, Y. Wang, Y. Fan, J. Ma, Layer-by-layer supramolecular assemblies based on linear and   star-shaped poly(glycerol methacrylate)s for doxorubicin delivery. J. Biomed. Mater. Res. Part A, 2013, 101A:   2164-2173.

57.A. Wang, H. Gao*, Y. Sun,   Y-L Sun, Y-W Yang, G. Wu, Y. Wang, Y. Fan, J. Ma*, Temperature- and   pH-responsive nanoparticles of biocompatible polyurethanes for doxorubicin   delivery. Int. J. Pharm., 2013, 441, 30-39.

58.W. Gu, Y. Ma, C. Zhu, B. Chen, J. Ma, H. Gao*,   Synthesis of cross-linked carboxyl poly(glycerol methacrylate) and its   application for the controlled release of doxorubicin. Eur.   J. Pharm. Sci., 2012, 47 (3), 556-563.

59.H. Gao, M. Elsabahy, E. Giger, D. Li, R. Prud’homme, J-C   Leroux, Self assembling properties of aminated poly(glycerol methacrylate)s. J   controlled release, 2012, 152, e142-143.

60.Y. N. Ma, H. Gao*, W. Gu, Y. Yang, Y.   Wang, Y. Fan, G. Wu, J. Ma, Carboxylated poly(glycerol methacrylate)s for   doxorubicin delivery. Eur. J. Pharm. Sci., 2012, 45,   65-72.

61.X. Y. Lu, H. Gao*, C. Li, Y. Yang, Y.   Wang, Y. Fan, G. Wu, J. Ma. Polyelectrolyte complex nanoparticles of amino   poly(glycerol methacrylate)s and insulin, Int. J. Pharm.,   2012, 423, 195-201.

62.H. Gao,   X. Y. Lu, Y. N. Ma, Y. W. Yang, J. F. Li, G. L. Wu, Y. N. Wang, Y. G. Fan, J.   B. Ma*, Amino poly(glycerol methacrylate)s for oligonucleic acid delivery   with enhanced transfection efficiency and low cytotoxicity, Soft Matter,   2011, 7, 9239-9247. (IDS Number: 822YE, IF=4.6)

63.H. Gao*, Y. N. Ma, X. Y. Lu, Y. R. Liang, B. Q.   Chen, J. B. Ma. PH-responsive nano-assemblies of amino poly(glycerol   methacrylate), Eur. Pol. J., 2011, 47, 1232-1239. (IDS   Number: 776GX, IF=2.9)

64.H. G. Fu, H. Gao*, G. L. Wu, Y. N.   Wang, Y. G. Fan, J. B. Ma. Preparation and tunable temperature-sensitivity of   biodegradable polyurethane nanoassemblies from diisocyanate and poly(ethylene   Glycol), Soft Matter, 2011, 7, 3546-3552. (IDS Number: 738XZ,   IF=4.6)

65.X. K. Sun, H. Gao*, G. L. Wu, Y. N.   Wang, Y. G. Fan, J. B. Ma. Biodegradable and temperature-responsive   polyurethanes for adriamycin delivery, Int. J. Pharm., 2011,   412, 52-58. (IDS Number: 793EH, IF=3.0)

66.H. Gao,   M. Elsabahy, E.V. Giger, D.K. Li, R.E. Prud’homme, J.C. Leroux,   Aminated linear and star-shape poly(glycerol methacrylate)s: synthesis and   self-assembling properties, Biomacromolecules, 2010, 11,   889-895. (IDS Number: 581WW, IF=5.8)

67.J. Leblond, H. Gao, A.   Petitjean, Leroux, J. C. Leroux, pH-Responsive molecular tweezers, J.   Am. Chem. Soc., 2010, 132, 8544-8545.

68.H. Gao, M.-C. Jones, J. Chen, Y.R. Liang, R. E. Prud’homme,   J.-C. Leroux, Hydrophilic nanoreservoirs embedded into polymeric   nanoparticles - An approach to compatibilize polar molecules with hydrophobic   matrices. Chem. Mater., 2008, 20, 4191-4193. (IDS   Number: 321BM, IF=8.5)

69.H. Gao,   M.-C. Jones, J. Chen, R. E. Prud’homme, J.-C. Leroux, Core cross-linked   reverse polymeric micelles. Chem. Mater., 2008, 20, 3063-3067. IDS Number: 297NM, IF=8.5

70.M.-C. Jones, H. Gao, J.-C. Leroux, Reverse   polymeric micelles for pharmaceutical applications. J. Controlled release,   2008, 132, 208-215. (IDS Number: 386SL, IF=7.3)

71.H. Gao, Y.-N. Wang, Y.-G. Fan, J.-B. Ma. Ethylenediamino bridged   bis(β-cyclodextrin)/ poly(DL-lactic-co-glycolic acid) nanoparticles prepared   by modified double emulsion method: effect of polyvinyl alcohol on   nanoparticle properties. J. Appl. Polym. Sci., 2008,   107, 571-576. (IDS Number: 229RP, IF=1.2)

72.H. Gao, M.-C. Jones, P. Tewari, M. Ranger, J.-C. Leroux, Star-Shaped   alkylated poly (glycerol methacrylate) reverse micelles: synthesis and   evaluation of their solubilizing properties in dichloromethane. J. Polym.   Sci. Part A: Polym. Chem., 2007, 45, 2425-2435. (IDS Number:   173SZ, IF=4.0)

73.H. Gao, Y.-N. Wang, Y.-G. Fan, J.-B. Ma. Conjugates of   poly(DL-lactide-co-glycolide) on amino cyclodextrins and their nanoparticles   as protein delivery system. J. Biomed Mater. Res. Pt A,   2007, 80A:111-122. (IDS Number: 114PN, IF=2.8)

74.H. Gao, Y.-N. Wang, Y.-G. Fan, J.-B. Ma. Conjugates of poly(DL-lactic   acid) with ethylenediamino or diethylenetriamino bridged   bis(beta-cyclodextrin)s and their nanoparticles as protein delivery systems. J   control release, 2006, 112, 301-311. (IDS Number: 057NA, IF=7.3)

75.H. Gao, Y.-N. Wang, Y.-G. Fan, J.-B. Ma. Interactions of   some modified mono- and bis-beta-cyclodextrins with bovine serum albumin. Bioorgan   & Med. Chem., 2006, 14, 131-137. (IDS Number: 989YB, IF=2.8)

76.H. Gao, Y.-N. Wang, Y.-G. Fan, J.-B. Ma. Synthesis of a   biodegradable tadpole-shaped polymer via the coupling reaction of polylactide   onto mono(6-(2-aminoethyl) amino-6-deoxy)- β -cyclodextrin and its   properties as the new carrier of protein delivery system. J   control release, 2005, 107, 158-173. (IDS Number:   970YW, IF=7.3)

专著:

1. 功能高分子材料,马建标主编,之第九章医用高分子材料, 第二版:化学工业出版社,2010.

专利:

1.       高辉; 孙现科; 马建标。具有pH响应性的生物降解聚氨酯材料的制备方法,ZL201010511225.5(已授权)。

2.       高辉; 顾文星; 马亚男; 陆学友; 马建标。一种具有pH响应性聚甲基丙烯酸甘油酯的制备方法,ZL201110282730.1(已授权)

3.       高辉;朱明冉。一种基于油相的两亲性高分子反相微乳的制备方法,201310454392.4

4.       高辉; 顾文星;王立志;郭盼。一种准嵌段共聚物反相高分子胶束的制备方法,201310420819.9

5.  高辉;李巧英;吴元昊;陈帅。具有可控的抑菌活性和细菌检测的自组装超分子纳米材料的制备方法,201710095911.0

6.  吕宏光;高辉;石季;郑雅丹。一种高聚集荧光发射的荧光标记分子及其制备方法,201510246913.6

 

获奖:

1. 高辉、杨英威、吕宏光、安金霞,超分子自组装在药物递送与生物成像中的应用基础研究,天津市自然科学二等奖(2019年)

2. 马建标、王亦农、王小红、高辉、范云鸽,天然生物高分子的修饰及其生物医学性能(2010ZR-3-006)天津市自然科学三等奖(2010年)

 

指导学生获得

1)第二届“天津市大学生创新、创业奖学金”顾文星获得“创新奖学金”优秀奖。

2)第十二届“挑战杯”全国大学生课外学术科技作品竞赛三等奖,天津市大学生课外学术科技作品竞赛特等奖:高分子的pH响应性能及其对抗癌药物的控制释放。人员:顾文星,朱楚宇、许祥、宋婧怡、王新雷

3)第八届中国青少年科技创新奖 顾文星

 

 

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