刘玉明-天津理工大学化学化工学院
化学化工学院
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教授
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刘玉明
2014-10-21 15:50:44   审核人:   (点击: )

刘玉明简介

姓名

刘玉明

性别

出生年月

1968.07

学历学位

博士

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职称

教授

系别

制药工程系

导师类型

硕导

电话

13702182883

Email

liuyuming@tjut.edu.cn

办公/科研室

19号楼407

所属学科

100701   药物化学

研究

方向

1. 具有重要生物活性天然先导化合物的发现及优化;

2. 针对重大疾病的创新药物研制;

3. 上市药品的质量标准提升和生产工艺改进。

讲授课程:本科生课程:天然药物化学;研究生课程:植化方法学

主要科研项目及代表性成果(包括鉴定项目、论文、专著、获奖、专利等)

科研项目:

1.国家自然科学基金面上项目:维药斯亚旦抗肝癌药效物质基础研究(81073153)2011.01-2013.1232万,项目负责人;

2.天津市科技发展计划项目:35种植物药标准提取物的研究(05ZHGCGX01500)2005.04-2007.0350万,参加;

3.国家自然科学基金项目:民族药马蹄金生物活性成分的研究(39960081)2000.01-2002.1212万,参加;

4.教育部“国家级大学生创新创业训练计划项目”:维吾尔药斯亚旦中抗肝癌先导物的发现(201210060001)2012.09-2014.072万,指导教师;

5.天津市教委科研项目:两亲性树型共聚物的分子设计及其多功能靶向药物载体的构建(20110501)2011.11-2014.104万,参加。

论文:

1.Yu-Ming Liu, Ya-Dong Feng, Xi Lu, Jian-Bing Nie, Wei Li, Li-Ning  Wang,Li-Jun Tian, Qing-Hua Liu. Isosteroidal alkaloids as potent dual-binding site  inhibitors of both acetylcholinesterase and butyrylcholinesterase from the  bulbs of Fritillaria walujewii. European Journal of Medicinal  Chemistry, 2017, 137: 280-291.

2.Yu-Ming  Liu,  Jian-Bing Nie,Lin-Na Sun,Qing-Hua Liu. Cytotoxic compounds from  Scolopendra subspinipes mutinlans. Heterocycles, 2016, 92 (2):  346-352.

3.Bao-Lin  Li, Bo Li, Rui-Lian Zhang, Ji-Jun Zhao, Xue-Feng Wang, Yu-Ming Liu,  Yan-Ping Shi, Jin-Biao Liu, Bao-Quan Chen. Synthesis and antiproliferative  evaluation of novel 1,2,4-triazole derivatives incorporating  benzisoselenazolone scaffold. Bioorganic &  Medicinal Chemistry Letters, 2016, 26 (4): 1279-1281.

4.Xiao-Yun  Fu, Sha Li, Fen Jing,_Xue-Feng Wang, Bao-Lin Li, Ji-Jun Zhao, Yu-Ming Liu,  Bao-Quan Chen. Synthesis and biological evaluation of novel 1,3,4-thiadiazole  derivatives incorporating benzisoselenazolone scaffold as potential antitumor  agents. Medicinal Chemistry, 2016, 12 (7): 631-639.

5.Lu  Sun, Yu-Ming Liu*,  Bao-Quan Chen, Qing-Hua Liu. New  phenolic compounds from the seeds of Nigella glandulifera and their  inhibitory activities against human cancer cells. Bioorganic & Medicinal  Chemistry Letters,  2015, 25 (18): 3864-3866.

6.Li-Na  Xuan, Peng Wang, Kai Zhang, Yan-Ping Shi, Yu-Ming Liu, Tao Zhu, Bao-Quan  Chen. Synthesis  and in vitro antiproliferative activity of novel benzisoselenazolone  derivatives. Medicinal Chemistry Research,  2015, 24 (2): 543-552.

7.Jie  Zhao, Li-Na Xuan, Hai-Chuan Zhao, Ji Chen, Xiao-Yun Fu, Sha Li, Fen Jing, Yu-Ming  Liu, Bao-Quan Chen. Synthesis and antitumor activities of 1,3,4-thiadiazole  derivatives possessing benzisoselenazolone scaffold. Chemical  Research in Chinese Universities, 2014, 30(5), 764-769.

8.Kai  Zhang, Peng Wang, Li-Na Xuan, Xiao-Yun Fu, Fen Jing, Sha Li, Yu-Ming Liu,  Bao-Quan Chen. Synthesis and antitumor activities of novel hybrid molecules containing  1,3,4-oxadiazole and 1,3,4-thiadiazole bearing Schiff base moiety. Bioorganic  & Medicinal Chemistry Letters, 2014, 24 (22): 5154-5156.

9.Yu-Ming  Liu,  Yu-Hu Jiang, Qing-Hua Liu, Bao-Quan Chen. Indazole-type alkaloids from the  seeds of Nigella  glandulifera.  Phytochemistry Letters, 2013, 6 (4): 556–559.

10.Yu-Ming Liu, Lu Sun, Qing-Hua  Liu, Shi-Rong Lu, Bao-Quan Chen. Dolabellane-type diterpene alkaloids from Nigella  glandulifera. Biochemical Systematics and Ecology, 2013, 49:  43–46.

11.Ying-Li Chen, Chun-Lan  Zhou, Zhen-Dan Ge, Yu-Fa Liu, Yu-Ming Liu, Wei-Yi Feng, Sen Li, Guo-You  Chen, Tai-Ming Wei.Composition and potential  anticancer activities of essential oils obtained from myrrh and frankincense.Oncology  Letters,  2013, 6 (4): 1140–1146.

12.Hai-Chuan Zhao,  Yan-Ping Shi, Yu-Ming Liu, Cai-Wen Li, Li-Na Xuan, Peng Wang, Kai  Zhang, Bao-Quan Chen.Synthesis and antitumor-evaluation of  1,3-selenazole-containing 1,3,4-thiadiazole derivatives. Bioorganic  & Medicinal Chemistry Letters, 2013, 23 (24): 6577-6579.

13.Yu Feng, Yu-Ming  Liu*, Qing-Hua Liu,Ying-Jie  Lei. Nigelactone, new phthalide glucoside from the seeds Nigella  glandulifera. Heterocycles, 2012, 85 (12): 3015-3019.

14.Jie Zhao, Bao-Quan  Chen, Yan-Ping Shi, Yu-Ming Liu, Hai-Chuan Zhao, Ji Cheng. Synthesis  and in vitro antitumor activity of 1,3,4-thiadiazole derivatives based on benzisoselenazolone.  Chinese Chemical Letters, 2012, 23 (7): 817-819.

15.Zhen-Hua Luo,  Shuang-Yan He, Bao-Quan Chen, Yan-Ping Shi, Yu-Ming Liu, Cai-Wen Li,  and Qiu-Sheng Wang. Synthesis and in Vitro Antitumor Activity of  1,3,4-Oxadiazole Derivatives Based on Benzisoselenazolone. Chemical &  Pharmaceutical Bulletin, 2012, 60 (7): 887–891.

16.Zhen-Hua Luo, Bao-Quan  Chen, Shuang-Yan He, Yan-Ping Shi, Yu-Ming Liu, Cai-Wen Li. Synthesis  and antitumor-evaluation of 1,3,4-thiadiazole-containing benzisoselenazolone  derivatives. Bioorganic & Medicinal Chemistry Letters, 2012, 22 (9): 3191-3193.  

17.Yu-Ming Liu, Qing-Hua LiuBao-Quan  Chen. A new flavonol glycoside from the seeds of Nigella glandulifera.  Natural Product Research, 2011, 25 (14):1334-1338.

18.Ze Tian, Yu-Ming  Liu, Si-Bao Chen, Jun-Shan Yang, Pei-Gen Xiao, Liao Wang, Erxi Wu.  Cytotoxicity of two triterpenoids from Nigella glandulifera, Molecules,  2006, 11 (9): 693-699.

19.Yu-Ming Liu, Jun-Shan Yang,  Qing-Hua Liu. A new alkaloid and its artificial derivative with indazole ring  from Nigella glandulifera. Chemical & Pharmaceutical Bulletin,  2004, 52 (4): 454-455.

20.刘玉明,田丽珺,胡栋,聂建兵. 4-N-苯胺基喹啉衍生物的合成及胆碱酯酶抑制活性.高等学校化学学报,2017, 383):392-397.

21.艾双艳,李卫国,冯亚东,田丽珺,刘玉明*.全蝎化学成分的研究.中成药,2017, 39(8): 1639-1641.

22.史林琦,路熹,孟令武,吕文婷,刘庆华,刘玉明*.新疆贝母鳞茎化学成分的分离与鉴定.中药材,2017, 40(9): 2098-2100.

23.李静,刘玉明*,刘庆华,李微.瘤果黑种草子中磷脂类成分的研究.中成药,201537(1)128-131.

24.刘玉明,蒋玉虎,张海滨.小儿清肺颗粒质量标准研究.中药新药与临床药理,2014,255):610-614.

25.蒋玉虎,刘玉明*,孙璐,李静.炉贝母不同提取物中贝母辛和贝母素乙含量的HPLC-ELSD测定.时珍国医国药,2014, 255):1051-1053.

26.刘玉明,路熹,蒋玉虎,刘庆华,高继光. HPLC-ELSD同时测定新疆贝母中贝母辛和贝母素乙的含量.中药材,2014, 375):827-829.

27.刘玉明,郑丽萍,王家美. 秦艽中龙胆苦苷纯化工艺的正交实验法优选.时珍国医国药,2012, 237):1596-1598.

28.刘玉明,李彩文. 天然药物化学教学方法的探讨.中国医药导报,2011,826):120-122.

29.史艳萍, 陈宝泉, 麻静, 刘玉明, 李彩文. 2-(2-取代-1,3,4-噻二唑-5-)-苯并异硒唑-3(2H)-酮衍生物的合成及体外抗癌活性, 化学学报2011,  69(21): 2561-2566.

30.杨梅,刘玉明,高瑞昶. 高效液相色谱法测定桑叶中1-脱氧野尻霉素的含量.武警医学,2007,18(2)121-123.

31.刘玉明,杨峻山,刘庆华. 瘤果黑种草子化学成分的研究.中国中药杂志,2005,3013):980-983.

32.刘玉明,杨峻山,刘庆华. 红花化学成分研究.中药材,2005,284):288-289.

33.梁光义,刘玉明,曹佩雪,徐必学,郝小江. 民族药马蹄金中多羟基化合物的研究.中南药学,2003,12):105-107.

34.刘玉明,梁光义,徐必学. 苗族药马蹄金化学成分的研究.天然产物研究与开发,2003,151):15-17.

35.刘玉明,梁光义,张建新,武孔云,徐必学,罗波. 马蹄金化学成分的研究.中国药学杂志,2002,378):577-579.

专著:

1.  刘玉明.《实用天然产物手册》萜类化合物分册(杨峻山主编)之第六章三环三萜类化合物,北京:化学工业出版社,2005.4

专利:

1.刘玉明,孙琳娜,聂建兵,田丽珺.国家发明专利.少棘蜈蚣中喹啉类生物碱作为治疗肿瘤药品的制备及应用,授权专利号ZL201510029556.8

2.刘玉明,陈宝泉,李彩文.国家发明专利.一种从杜仲果中提取桃叶珊瑚苷的工艺方法,授权专利号ZL201010297478.7

3.刘玉明,孙琳娜,李静.国家发明专利.一种从斯亚旦中提取异株五加甲苷的方法,申请号201310619087.6

4.刘玉明,冯亚东,孙璐,聂建兵,路熹,孙琳娜.国家发明专利.常春藤皂苷元类化合物作为治疗肝癌药品的应用及其制备,申请号201410214316.0

5.陈宝泉,罗振华,刘玉明,史艳萍,赵海川,程吉,赵婕.国家发明专利.2-(2-取代-1,3,4-噁二唑-5-)-苯并异硒唑酮衍生物的制备方法,申请号201110411172.4

6.陈宝泉,史艳萍,麻静,卢学磊,李彩文,刘玉明.国家发明专利.基于苯并异硒唑酮结构的1,3,4-噻二唑(噁二唑)衍生物及其制备方法和应用,授权专利号ZL201010213585.7

7.梁光义,徐必学,刘昌孝,黄正明,曹佩雪,蔡泽贵,刘玉明.国家发明专利.N-(N-苯甲酰基-苯丙氨酰基)-苯丙氨酸二肽衍生物及其制备方法和用途,授权专利号ZL200610201016.4

8.梁光义,刘玉明,徐必学.国家发明专利.苯丙氨醇类化合物作为制备治疗乙肝药品的应用及其制备方法,授权专利号ZL02160309.X

获奖:

1. 天津科技进步三等奖(2008年度),35种植物药标准提取物的研究。

 

 

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