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高辉
2014-10-21 15:30:23     (点击: )

高辉简介

姓名

高辉

性别

出生年月

1973.12

学历学位

博士

职称

教授

系别

制药系

导师类型

硕导

电话

022-60214251

Email

Hgao@tjut.edu.cn

办公/

科研室

19号楼501

所属学科

0817 化学工程与技术 /100701 药物化学

研究

方向

1. 生物医用高分子合成及其性能研究

2. 抗癌药物、蛋白质、肽类药物等的缓、控释体系

3. 环境响应性智能给药系统

讲授课程: 药用高分子材料 药事管理学  药学专业英语

人才称号:教育部新世纪优秀人才支持计划;“天津市131创新型人才培养工程”第一层次人选

学术兼职:国家自然科学基金评阅人,担任Adv. Mater.,  ACS App. Mater. & Inter., Mol. Pharm., Biomacromolecules, J. Control.  Release, Eur. J. Pharm. Biopharm.等期刊特邀审稿人。

主要科研项目及代表性成果(包括鉴定项目、论文、专著、获奖、专利等)

项目:

1. 国家自然科学基金项目:近红外聚集诱导发光和活性氧参与的高效基因载体的构建(21674080),2017.01-2020.1266万,主持;

2. 国家自然科学基金项目:基于beta-环糊精的反相高分子胶束的构建及其在肽类药物传输中的应用(21374079),2013.01-2017.1283万,主持

3. 国家自然科学基金项目: beta-环糊精高分子的合成、反相胶束的构建及其在肽类药物控制释放中的应用(21244004),2013.01-2013.1210万,主持;

4. 国家自然科学基金项目:含多氢键给体的高分子的合成及其作为基因载体的性能研究(21074092),2011.01-2013.12, 35万,主持

5. 2012年入选天津市高校“中青年骨干创新人才培养计划”201212月—201511月,45万,主持

6. 天津市自然科学基金:侧链降解型聚阳离子基因载体的合成及其性能研究(10JCYBJC268002010.10  - 2013.0910万,主持;

7. 973计划前期专项:新型生物降解高分子纳米材料的合成及其环境响应性能(2009CB626612),2009.04-11.0855万元,与南开大学马建标教授合作项目;是天津理工大学方负责人(结题);

7. 天津市高等学校科技发展基金计划项目:羧基聚甲基丙烯酸甘油酯的合成及对阿霉素的控制释放200905052009.12-2012.123万元,主持(结题)。

8. 教育部新世纪优秀人才支持计划,2012.01-2014.1250万,主持;

9. 2015年入选“天津市131创新型人才培养工程”第一层次人选

论文:

1.Q. Li, Y. Wu, H. Lu, X. Wu, S. Chen, N. Song, Y.-W. Yang*, Hui  Gao*, Construction of supramolecular nanoassembly for responsive  bacterial elimination and effective bacterial detection, ACS Appl. Mater.  Interfaces, 2017, 9, 10180-10189.

2.T. Wang, Q. Chen, H. Lu W. Li, Z. Li, J. Ma, H. Gao,* Shedding  PEG palisade by temporal photo-stimulation and intracellular reducing milieu  for facilitated intracellular trafficking and DNA releasing, Bioconjug.  Chem.2016, 27, 1949-1957.

3.X.  Q. Han, Q. X. Chen, H. G. Lu, P. Guo, W. Li, G. L. Wu, J. B. Ma, H.Gao*,  Incorporation of an aggregation-induced-emissive tetraphenylethene derivative  into cationic gene delivery vehicles manifested the nuclear translocation of  uncomplexed DNA, Chem. Commun., 2016, 52, 3907-3910.

4.H. Lu,* Y. Zheng, X. Zhao, L. Wang, S. Ma, X. Han, B. Xu, W.  Tian, H. Gao,* Highly efficient farRed/Near-infrared solid  fluorophores: aggregation-induced emission, intramolecular charge transfer,  twisted molecular conformation, and bioimaging application. Angew. Chem.  Int. Ed., 2016, 55, 155 -159.

5.Y. Long, W. Gu, C. Pang, J. Ma, H. Gao, * Construction  of coumarin-based cross-linked micelles with pH responsive hydrazone bond and  tumor targeting moiety, J. Mater. Chem .B, 2016, 4, 1480-1488.

6.C. Fan, C. Pang,* X. Liu, J. Ma, H. Gao,* Self-curing  furan-based elastic thermosets derived from citric acid, Green Chem. 2016,18,  6320-6328.

7.Y. Wu, Q. Chen, Q. Li, H. Lu, X. Wu, J. Ma,H. Gao*,Daylight-stimulated antibacterial  activity for sustainable bacterial detection and inhibition, J. Mater.  Chem. B, 2016, 4, 6350-635.

8.J.  Wen, H. Lu*, D. Liu, H.  Gao*, Fabrication of macroporous protein-containing  films through the reverse emulsions approach featuring  β-cyclodextrin-conjugated PEG-PLGA copolymers, Chinese J. Polym. Sci.,  2016, 34, 730-738

9.X.  Q. Han, Q. X. Chen, H. G. Lu, J. B. Ma, H. Gao* Probe Intracellular  Trafficking of Polymeric DNA Delivery Vehicle by Functionalization with  Aggregation-induced Emissive Tetraphenylethene Derivative, ACS Appl Mater  Inter, 2015, 7, 28494-28501.

10.Q. Li, S Xu, H. Zhou, X. Wang, B. Dong, H. Gao,* J.  Tang,* Y. Yang.* pH and Glutathione Dual-Responsive Dynamic  Cross-Linked Supramolecular Network on Mesoporous Silica Nanoparticles for  Controlled Anticancer Drug Release, ACS  Appl. Mater. Interfaces,2015, 7,  28656-28664.

11.X. Han, D. Liu, T. Wang, H. Lu, J. Ma, Q. Chen,* H. Gao,*  Aggregation-induced-emissive molecule incorporated into polymeric  nanoparticulate as FRET donor for observing doxorubicin delivery. ACS Appl. Mater. Interfaces,  2015, 7 (42), 23760-23766.

12.P. Guo, W. Gu, Q. Chen, H. Lu, X. Han, W. Li, H. Gao,*  Dual functionalized amino poly(glycerol methacrylate) with guanidine and  Schiff-base linked imidazole for enhanced gene transfection and minimized  cytotoxicity. J. Mater. Chem., B, 2015, 3, 6911-6918.

13.Y. Zhuang, W. Gu, J. Yang, X. Chen, H. Gao,*Supramolecular nanoparticles constructed by balancing  forces between attractive host-guest and repulsive electrostatic interactions  in two positively charged polymers. RSC Adv.,2015, 5,  96464-96471.

14.Y. Wu, Y. Long, Q.-L. Li, S. Han, J. Ma, Y.-W. Yang,* H. Gao,*  Layer-by-layer (LBL) self-assembled biohybrid nanomaterials for efficient  antibacterial applications, ACS Appl. Mater. Interfaces,2015,  7, 17255-17263.

15.H. Gao, H. Takemoto, Q. Chen, M.  Naito, H. Uchida, X. Liu, K. Miyata,* K. Kataoka,* Regulated protonation of  polyaspartamide derivatives bearing repeated aminoethylene side chains for  efficient intracellular siRNA delivery with minimal cytotoxicity. Chem.  Commun.,2015, 51, 3158-3161.

16.W.-X. Gu, Q.-L. Li, H. Lu, L. Fang, Q. Chen, Y.-W. Yang,* H.  Gao,* Construction of stable polymeric vesicles based on  azobenzene and beta-cyclodextrin grafted poly(glycerol methacrylate)s for  potential applications in colon-specific drug delivery. Chem. Commun.,2015, 51, 4715-4718.

17. W.-X. Gu, M. Zhu, N. Song, X. Du,  Y.-W. Yang, H. Gao,*Reverse  micelles based on biocompatible β-cyclodextrin conjugated polyethylene glycol  block polylactide for protein delivery. J.  Mater. Chem. B,2015, 3, 316-322.

18.X Du, N.  Song, Y-W Yang, G Wu, J Ma, H Gao,* Reverse micelles based on  β-cyclodextrin-incorporated amphiphilic polyurethane copolymers for protein  delivery. Polym. Chem. 2014, 5300-5309. (IF=5.37)

19.W Gu, Y-W  Yang, J Wen, H Lu, H Gao,* Construction of reverse vesicles from  pseudo-graft poly(Glycerol Methacrylate)s via cyclodextrin-cholesterol  interaction. Polym. Chem.2014, 5, 6344-6349. (IF=5.37

20.Q-L Li,  L-Z Wang, X Qiu, Y-L Sun, P Wang, Y Liu, F Li, A-D Qi, H Gao,* Y-W  Yang,* Stimuli-responsive biocompatible nanovalve based on β-cyclodextrin  modified poly(glycidyl methacrylate). Polym. Chem.2014,  5, 3389-3395. (IF=5.37)

21.Q-L Li,W Gu, H. Gao,* Yang, Y.-W,* Self-assembly and applications of  poly(glycidyl methacrylate)s and their derivatives. Chem. Commun.2014,  50, 13201-13215. (IF: 6.718)

22.L Wang,  Y.-W. Yang, M. Zhu, G Qiu, G Wu, H Gao,* β-Cyclodextrin-conjugated  amino poly(glycerol methacrylate)s for efficient insulin delivery. RSC  Adv, 2014, 4, 6478-6485. (IF=3.70)

23.Q-L Li,Y Sun,Y -L Sun, J Wen, Y Zhou, Q Bing, L Isaacs, Y Jin, H  Gao,* Y-W Yang,* Mesoporous silica nanoparticles coated by layer-by-layer  self-assembly using cucurbit[7]uril for in vitro and in vivo anticancer drug  release.Chem Mater, 2014, 26, 6418-6431. (IF= 8.535)

24.D-E Liu, H  Han, H Lu, G Wu, Y Wang, J Ma, H Gao,* Synthesis of amphiphilic  polyaspartamide derivatives and construction of reverse micelles. RSC  Adv, 2014, 4, 37130-37137. (IF=3.70)

25.H Han, D  -E Liu, H  Lu, W-X Gu, H Gao,* Construction of micelles  based on biocompatible pseudo-graft polymers via b-cyclodextrin/cholesterol  interaction for protein delivery. RSC Adv, 2014, 4,  40882-40891. (IF=3.70)

26.Y Sun, Y-L  Sun, L Wang, J Ma, Y-W Yang,* H Gao,* Nanoassembles constructed from  mesoporous silica nanoparticles and surface-coated multilayer  polyelectrolytes for controlled drug delivery. Micropor Mesopor Mater, 2014,185, 245-253. (IF=3.37)

27.Z Liang, M  Zhu, Y-W Yang, H Gao,* Antimicrobial activities of polymeric  quaternary ammonium salts from poly(glycidyl methacrylate)s. Polym.  Adv. Technol. 2014, 25, 117-122. (IF=1.64)

28.H Gao,* Z Liang,  X Wu, C Li, Y-W Yang, G. Wu, J Ma, Quaternized poly(Glycerol Methacrylate)s  for enhanced pDNA delivery. 2013, J. Controlled Release, 172,  e104-e105. (IF=7.26)

29.C Li, Y-W  Yang, Z-X Liang, G-L Wu, H Gao,* Post-modification poly(glycidyl  methacrylate)s with alkyl amine and isothiocyanate for effective pDNA  delivery. Polym Chem, 2013, 4, 4366-4374. (IF=5.37)

30.Z Liang,  Xi Wu, Y-W Yang, C Li, G Wu, H Gao,* Quaternized amino  poly(glycerol-methacrylate)s for enhanced pDNA delivery. Polym Chem,  2013,4, 3514-3523. (IF=5.3)

31.Y Sun, H Gao,* Y-W Yang, A Wang, G Wu, Y Wang, Yu Fan, J Ma,Layer-by-layer supramolecular assemblies based on linear and  star-shaped poly(glycerol methacrylate)s for doxorubicin delivery. J Biomed Mater Res Part A, 2013, 101A: 2164-2173.(IF=2.6)

32.A Wang, H  Gao,* Y Sun, Y-L Sun, Y-W Yang, G Wu , Y Wang , Y Fan, J Ma, *Temperature-  and pH-responsive nanoparticles of biocompatible polyurethanes for  doxorubicin delivery. Int J Pharm,2013,441,  30-39. (IF=3.2)

33.W Gu, Y  Ma, C Zhu, B Chen, J Ma, H Gao,* Synthesis of cross-linked carboxyl  poly(glycerol methacrylate) and its application for the controlled release of  doxorubicin.Eur J Pharm Sci,2012, 47 (3), 556-563. (IF=3.2)

34.H Gao, M  Elsabahy, E Giger, D Li, R Prud’homme,  J-C Leroux, Self assembling  properties of aminated poly(glycerol methacrylate)s. J controlled  release, 2012, 152, e142-143. (IF=5.7)

35.Y N Ma,  HGao,* W Gu, Y Yang, Y Wang, Y Fan, G Wu, J Ma,  Carboxylated poly(glycerol methacrylate)s for doxorubicin delivery. Eur  J Pharm Sci,2012, 45, 65-72. (IF=3.3)

36.X Y Lu, H  Gao,* C Li, Y Yang, Y Wang, Y Fan, G Wu, J Ma. Polyelectrolyte  complex nanoparticles of amino poly(glycerol methacrylate)s and insulin,  Int J Pharm, 2012, 423, 195-201. (IF=3.6)

37.H Gao, Lu X Y, Y N Ma, Y W Yang, J F Li, G L Wu, Y N Wang, Y G Fan,  and Ma J B*. Amino poly(glycerol methacrylate)s for oligonucleic acid  delivery with enhanced transfection efficiency and low cytotoxicity,Soft  Matter, 2011, 7: 9239-9247. IDS Number: 822YE , IF=4.6);

38.H Gao,* Y N Ma, X Y Lu, Y R Liang, B Q Chen, and J B Ma. PH-responsive  nano-assemblies of amino poly(glycerol methacrylate),Eur Pol J,  2011, 47:1232-1239IDS  Number: 776GX,  IF=2.9);

39.H G Fu, H Gao,* G L Wu, Y N Wang, Y G Fan, and J B Ma.  Preparation and tunable temperature-sensitivity of biodegradable polyurethane  nanoassemblies from diisocyanate and poly(ethylene Glycol), Soft Matter,  2011, 7: 3546-3552IDS  Number: 738XZ, IF=4.6);

40.X K Sun, H Gao,* G L Wu, Y N Wang, Y G Fan, and J B Ma.  Biodegradable and temperature-responsive polyurethanes for adriamycin  delivery, Int J Pharm, 2011,412:52-58IDS Number: 793EH, IF=3.0);

41.H. Gao, M. Elsabahy, E.V. Giger, D.K. Li,R.E. Prud’homme,  J.C. Leroux, Aminated linear and star-shape poly(glycerol methacrylate)s:  synthesis and self-assembling properties, Biomacromolecules,  2010, 11: 889-895.IDS  Number: 581WW, IF=5.8);

42.J. Leblond,; H. Gao, A. Petitjean, Leroux, J.C. Leroux,  pH-Responsive molecular tweezers,J Am Chem Soc, 2010, 1328544-8545. IDS Number:, IF=8.6);

43.H. Gao, M.-C. Jones, J. Chen, Y.R. Liang, R. E. Prud’homme, J.-C.  Leroux, Hydrophilic nanoreservoirs embedded into polymeric nanoparticles - An  approach to compatibilize polar molecules with hydrophobic matrices. Chem  Mater,2008; 20: 4191–4193. IDS Number: 321BM, IF=8.5);

44.H. Gao, M.-C. Jones, J. Chen, R. E. Prud’homme, J.-C. Leroux, Core  cross-linked reverse polymeric micelles. Chem Mater, 2008; 20:  3063–3067. IDS  Number: 297NM, IF=8.5);

45.M.-C. Jones, H. Gao, J.-C. Leroux, Reverse polymeric  micelles for pharmaceutical applications. J. Controlled release,  2008;132:208-215. IDS  Number: 386SL, IF=7.3);

46.H. Gao, Y.-N. Wang, Y.-G. Fan, J.-B. Ma. Ethylenediamino bridged  bis(β-cyclodextrin)/ poly(DL-lactic-co-glycolic acid) nanoparticles prepared  by modified double emulsion method: effect of polyvinyl alcohol on  nanoparticle properties. J Appl Polym Sci, 2008; 107: 571–576. IDS Number: 229RP, IF=1.2);

47.H. Gao, M.-C. Jones, P. Tewari, M. Ranger, J.-C. Leroux, Star-Shaped  alkylated poly (glycerol methacrylate) reverse micelles: synthesis and  evaluation of their solubilizing properties in dichloromethane. J Polym  Sci Part A: Polym Chem,  2007; 45:2425-2435. IDS Number: 173SZ, IF=4.0);

48.H. Gao, Y.-N. Wang, Y.-G. Fan, J.-B. Ma. Conjugates  of poly(DL-lactide-co-glycolide) on amino cyclodextrins and their nanoparticles  as protein delivery system. J Biomed Mater Res Pt A,2007;  80A:111-122. IDS  Number: 114PN, IF=2.8);

49.H. Gao, Y.-N. Wang, Y.-G. Fan, J.-B. Ma. Conjugates of poly(DL-lactic  acid) with ethylenediamino or diethylenetriamino bridged  bis(beta-cyclodextrin)s and their nanoparticles as protein delivery systems. J  control release, 2006; 112:301-311. IDS Number: 057NA, IF=7.3);

50.H. Gao, Y.-N. Wang, Y.-G. Fan, J.-B. Ma. Interactions of some modified  mono- and bis-beta-cyclodextrins with bovine serum albumin. Bioorgan  & Med Chem, 2006; 14:131-137. IDS Number: 989YB, IF=2.8);

51.H. Gao, Y.-N.  Wang, Y.-G. Fan, J.-B. Ma. Synthesis of a biodegradable tadpole-shaped  polymer via the coupling reaction of polylactide onto mono(6-(2-aminoethyl)  amino-6-deoxy)- β -cyclodextrin and its properties as the new carrier  of protein delivery system. J control release, 2005;  107:158-173.IDS  Number: 970YW, IF=7.3

专著:

1. 功能高分子材料,马建标主编,之第九章医用高分子材料,  第二版:化学工业出版社,2010.

专利:

52.高辉; 孙现科; 马建标。具有pH响应性的生物降解聚氨酯材料的制备方法,ZL201010511225.5(已授权)。

53.高辉; 顾文星; 马亚男; 陆学友; 马建标。一种具有pH响应性聚甲基丙烯酸甘油酯的制备方法,ZL201110282730.1(已授权)

54.高辉;朱明冉。一种基于油相的两亲性高分子反相微乳的制备方法,201310454392.4

55.高辉;顾文星;王立志;郭盼。一种准嵌段共聚物反相高分子胶束的制备方法,201310420819.9

获奖:

1马建标、王亦农、王小红、高辉、范云鸽,天然生物高分子的修饰及其生物医学性能(2010ZR-3-006)天津市自然科学三等奖(2010年);

 

指导学生获得

1)第二届“天津市大学生创新、创业奖学金”顾文星获得“创新奖学金”优秀奖。

2)第十二届“挑战杯”全国大学生课外学术科技作品竞赛三等奖,天津市大学生课外学术科技作品竞赛特等奖:高分子的pH响应性能及其对抗癌药物的控制释放。人员:顾文星,朱楚宇、许祥、宋婧怡、王新雷

3)第八届中国青少年科技创新奖顾文星

 

 

 

 

 
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