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关于中科院兰州化学物理研究所徐森苗研究员学术报告的通知
2017-10-10 09:46:28     (点击: )

报告题目:Copper-CatalyzedAsymmetric Synthesis of Functionalized and Cyclic α-Amino Boronate Esters

人:徐森苗研究员,中科院兰州化学物理研究所

报告时间:20171016(周一)上午1000 – 1100

报告地点:19号楼226学术报告厅

要:α-Amino boronateesters have emerged as important constituents in protease inhibitors and usefulbuilding blocks in synthetic chemistry.[1]However, most of currentmethods rely on diasteroselective synthesis with involvement of stoichiometricamount of chiral auxiliaries. Although some groups have succeeded in thesynthesis of optically active α-amino boronate esters via asymmetric catalysis,[2-8]the reactions are still very limited. For examples, catalyticasymmetric synthesis of functionalized chiralα-amino boronate estersand cyclic chiralα-amino boronateesters are virtually unexpolored.

To this end, we have developed copper-catalyzed asymmetric conjugate borylationof β-aza-α,β-unsaturated compounds and dearomatizative borylation of indolederivatives for the first time, which allows for accessing a series of stablefunctionalized chiral α-amino boronate esters in good yields andenantioselectivities (up to 97% ee) under mild reaction conditions. The currentmethod is also applicable for gram-scale synthesis without erosion of anystereoselectivity.  

http://www.licp.cas.cn/rcjy/zgjgwry/xsm/201503/W020150325330634104850.jpg    报告人简介:徐森苗,2009年7月上海有机化学研究所毕业,获得理学博士学位,先后在美国波士顿学院(Boston College)(2013.9-2015.2)、美国俄勒冈大学(Universityof Oregon)(2010.10-2013.7)、日本京都大学化学系(2009.9-2010.10)从事博士后研究工作,2015.3到中国科学院兰州化学物理研究所工作,入选第十二批青年千人计划。先后在J. Am. Chem. Soc.、Angew. Chem. Int. Ed等国际知名杂志发表论文十几篇。

 

 
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