报告题目：Rhodamine Dyes, from New Synthesis to New Structures to NewApplications
报告时间：2017年7月19日 (周三) 上午10：00 – 11：00
Abstract：Fluorescent dyes are the cornerstones of avariety of modern biomedical technologies, including DNA sequenching,flowcytometry, fluorescence in-situ hybridization, and various forms of invitro or in vivo imaging modalities, etc. Development of novel fluorescentscaffolds and functional dyes to meet the ever-growing need from the biomedicalcommunity has been an ongoing research focus of synthetic dye community.
Ourgroup has a strong interest on xanthene dyes, a classic scaffold firstsynthesized by von Baeyer in the last 1870s. They have been tailored intolabels, probes, donors and more. However, development of novel molecular toolsbased on xanthenes may be limited by the available synthetic approaches. Overthe years, we have developed multiple new preparations of the xanthenescaffold. With these new preparations, we were able to access xanthenoids,which could not be prepared via alternative approaches.
Someof these xanthenoids exhibit strong absorption and emission in the nearinfrared or even infrared regaion, some are sterically protected to such anextent that it is not prone to nucleophilic attack by high concentration ofthiols or hydroxide; some have been rendered into a template forphoto-triggered drug-release; some are able to yield an intense fluorescence turn-onsignal in the presence of the analyte-of-interest; and some others haveexhibited potent anti-microbial activity against a range of multi-drug resistantpathogens.
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2015-now Professor, ECUST
2010-2015 AssociateProfessor, ECUST
2007-2010 Postdoc University of Texas at Austin Prof.Eric V. Anslyn
2002-2007 Ph.D. Louisiana State University Prof.Robert M. Strongin
1997-2002 B.S. University ofScience and Technology of China
2014 UniversityTeaching Award for Graduate Education（研究生优秀教师）
2013 ShanghaiRising-Star talent award（上海市科委青年科技启明星）
2012 JuniorFaculty Award, School of Pharmacy, ECUST（药学院优秀青年教师）
2012 Tianding-DongyueAward for Teaching, ECUST（天鼎-东岳奖教金特等奖）
2007-2010 PostdoctoralFellowship from Henry Ford Hospital
2003 TeachingAward for General Chemistry Laboratory
1)Novelnear-infrared dyes absorbing and emitting beyond 800 nm;
3)Environmentallyinsensitive, large cross-section (>800 GM) two-photon dyes;
4)Photo-triggeredrelease of bioactive molecules, e.g. NO, OONO-, CO, 1O2,etc.
5)Fluorescentprobes via covalent assembly principle, e.g. OONO-, MeHg+,Sarin, etc.
6)Diverse-orientedsynthesis of dye library in search for bioactive compounds, e.g. antibioticactivity.